5/10/2025
Last update
5/10/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
USERS' SCORE
Good
Based on 18 Reviews
8.1
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Pantothenic Acid (Vitamin B-5) (From Calcium Pantothenate)
500 mg
10,000%
Calcium (From Calcium Pantothenate)
45 mg
3%
Top Medical Research Studies
9.5
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
Most Useful Reviews
10
Acne cleared completely
8 people found this helpful
I achieved complete clearance of my cystic acne within 6 months thanks to pantothenic acid, which significantly reduced sebum production. Starting at 1000 mg daily for 3 months allowed my acne to decrease by 70-80%. Increasing my dosage to 1500 mg daily cleared my skin almost entirely. I've been on it for nearly a year now, and my skin remains clear.
Read More
9
Supports adrenal health
6 people found this helpful
As someone suffering from late-stage adrenal fatigue due to MCAS, this product, along with vitamin C, magnesium, and omega 3s, is essential for me. It’s crucial to take pantothenic acid multiple times a day, especially when adrenal function is significantly impaired.
Read More
7.5
Improved adrenal function
40 people found this helpful
Adrenal fatigue (AFS) has caused me significant issues, particularly with irritable bowel syndrome (IBS) due to stress. The negative impact on my mental health was notable. By taking 8 to 10 tablets daily to maintain pantothenic acid levels, I experienced considerable improvement in both IBS and depressive symptoms linked to AFS. I realised my intake of B100 wasn't sufficient, leading me to increase magnesium from 400 mg to 1200 mg daily to enhance adrenal function. It's been stable thus far, showing positive results.
Read More
Medical Researches
SCIENTIFIC SCORE
Likely Very Effective
Based on 1 Research
9.5
- All Researches
9.5
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Read More
User Reviews
USERS' SCORE
Good
Based on 18 Reviews
8.1
- All Reviews
- Positive Reviews
- Negative Reviews
10
Acne cleared completely
8 people found this helpful
I achieved complete clearance of my cystic acne within 6 months thanks to pantothenic acid, which significantly reduced sebum production. Starting at 1000 mg daily for 3 months allowed my acne to decrease by 70-80%. Increasing my dosage to 1500 mg daily cleared my skin almost entirely. I've been on it for nearly a year now, and my skin remains clear.
Read More
9
Supports adrenal health
6 people found this helpful
As someone suffering from late-stage adrenal fatigue due to MCAS, this product, along with vitamin C, magnesium, and omega 3s, is essential for me. It’s crucial to take pantothenic acid multiple times a day, especially when adrenal function is significantly impaired.
Read More
7.5
Improved adrenal function
40 people found this helpful
Adrenal fatigue (AFS) has caused me significant issues, particularly with irritable bowel syndrome (IBS) due to stress. The negative impact on my mental health was notable. By taking 8 to 10 tablets daily to maintain pantothenic acid levels, I experienced considerable improvement in both IBS and depressive symptoms linked to AFS. I realised my intake of B100 wasn't sufficient, leading me to increase magnesium from 400 mg to 1200 mg daily to enhance adrenal function. It's been stable thus far, showing positive results.
Read More
9
Skin condition enhanced
13 people found this helpful
The vitamin I ordered on my doctor's advice is crucial for my treatment. After nearly a month, I saw my skin transform from dry and itchy to smooth and velvety within a week. This vitamin has become my best ally and I plan to continue taking it with short breaks.
Read More
9
Energy levels boosted
7 people found this helpful
In just two days of taking this product, I felt invigorated, as if the lights had been switched on in my body. After stopping thyroid meds, I struggled with fatigue, but now with one capsule yesterday and two today, I'm feeling energetic again. It seems like something I’ve been deficient in, and I am grateful for this boost!
Read More
Frequently Asked Questions
9
Energy levels boosted
7 people found this helpful
In just two days of taking this product, I felt invigorated, as if the lights had been switched on in my body. After stopping thyroid meds, I struggled with fatigue, but now with one capsule yesterday and two today, I'm feeling energetic again. It seems like something I’ve been deficient in, and I am grateful for this boost!
7.5
Acne reduced significantly
1 people found this helpful
I purchased this supplement for my son, who struggled with serious acne. After a month of use, I'm pleased to report that his acne has noticeably diminished. This product is terrific and remarkably affordable—thanks, iHerb!
7.5
Gradual skin improvement
2 people found this helpful
With regular use of this vitamin over two months, I noticed an improvement in my skin, which had been plagued by acne for five years. I've not seen a change until I began using this product.
10
Acne cleared completely
8 people found this helpful
I achieved complete clearance of my cystic acne within 6 months thanks to pantothenic acid, which significantly reduced sebum production. Starting at 1000 mg daily for 3 months allowed my acne to decrease by 70-80%. Increasing my dosage to 1500 mg daily cleared my skin almost entirely. I've been on it for nearly a year now, and my skin remains clear.
9
Quick results observed
1 people found this helpful
After starting this vitamin B5, I was inspired by a video showing how it helped someone else's son with acne. Within just a week, I noticed a significant difference with four pills during each meal three times a day. I need to reorder, and the delivery was impressively quick.
7.5
Nails and hair thrive
1 people found this helpful
I had a severe vitamin deficiency due to my autoimmune disorder, which affected my hair and nails significantly. A friend introduced this supplement to me, and I've since realised my nails are much stronger and growing longer, as well as my hair thickening remarkably. I wasn't aware that this supplement contained B5, which is also in many hair products. I eat healthily, but this product quickly delivered visible results.
6
Slight improvement noted
I tried this product to help my acne. Although uncertain if it had a significant effect, I think I can see a slight positive difference. I will give it more time and plan to order it again in a couple of months to assess if it continues to improve.
9
Supports adrenal health
6 people found this helpful
As someone suffering from late-stage adrenal fatigue due to MCAS, this product, along with vitamin C, magnesium, and omega 3s, is essential for me. It’s crucial to take pantothenic acid multiple times a day, especially when adrenal function is significantly impaired.
7.5
Autoimmune condition managed
5 people found this helpful
For many years, I've been taking NOW B5 without any stomach issues, and it has significantly helped keep my autoimmune condition in check when combined with NOW Niacinamide (B3) as recommended by a Naturopath. I take 2 x B5 and 1 Niac twice daily. Additionally, B5 aids in calming my nerves.
7.5
Improved adrenal function
40 people found this helpful
Adrenal fatigue (AFS) has caused me significant issues, particularly with irritable bowel syndrome (IBS) due to stress. The negative impact on my mental health was notable. By taking 8 to 10 tablets daily to maintain pantothenic acid levels, I experienced considerable improvement in both IBS and depressive symptoms linked to AFS. I realised my intake of B100 wasn't sufficient, leading me to increase magnesium from 400 mg to 1200 mg daily to enhance adrenal function. It's been stable thus far, showing positive results.
7.5
Skin and hair growth
1 people found this helpful
I am about to place my second order after taking these capsules for less than a year. I've noticed improvements not only in my skin but also slight hair and nail growth. For beginners, I recommend taking one capsule per day for a week before increasing the dosage. In my case, taking 4 capsules has proven beneficial.
9.5
We investigated how calcium, specifically in the form of two-dimensional layered calcium disilicide nanoparticles (CSNs), can play a role in treating rheumatoid arthritis (RA). Unlike typical RA treatments that primarily focus on reducing inflammation, we observed that CSNs have multifunctional properties that can address the inflammatory aspect while also promoting bone health and repair.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
Through a process called hydrolysis, CSNs release several beneficial components, including hydrogen gas, calcium hydroxide, and silica. Each of these components contributes uniquely: hydrogen helps reduce harmful radicals and aids in adjusting surrounding immune cell behavior; calcium hydroxide counters the acidity that can worsen bone loss; and dissolved calcium works with phosphates to encourage bone formation.
We found that the application of CSNs had promising results in tests conducted on both mouse and rabbit models of arthritis. This approach not only targets inflammation but also fosters a healthier bone environment, showing potential as a strong therapeutic option for those living with RA. With high biocompatibility and prospects for clinical transformation, this research suggests a new direction in handling autoimmune disorders using calcium-based therapies.
References
- Ji P, Qiu S, Huang J, Wang L, Wang Y, et al. Hydrolysis of 2D Nanosheets Reverses Rheumatoid Arthritis Through Anti-Inflammation and Osteogenesis. Adv Mater. 2025;37:e2415543. 10.1002/adma.202415543
